Genomics

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Identification of novel SNP candidates associated with chemo-responsiveness in colorectal cancers


ABSTRACT: Identificaiton of novel single-nucleotide polymorphism (SNP) candidates associated with chemo-responsiveness in colorectal cancers using microarray Response rates of 104 colorectal cancer patients to established regiments (FL, CAPE, FLOX, FLIRI) were evaluated by histoculture drug response assay. Affymetrix SNP 5.0 chips were used to determine genotypes of the same colorectal cancer patients. SNPs associated with chemosensitivity to standard regimens were identified by genome-wide association study. FL: 5-FU + Leucovorin; CA: Capecitabine, FLOX: 5-FU + Leucovorin + Oxaliplatin, FLIRI: 5-FU + Leucovorin + Irinotecan

ORGANISM(S): Homo sapiens

PROVIDER: GSE16718 | GEO | 2010/06/01

SECONDARY ACCESSION(S): PRJNA117479

REPOSITORIES: GEO

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