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BRD4-chromatin interaction in reporter KBM7 cells (REDS15) with purine metabolism perturbation

ABSTRACT: To investigate whether BRD4-chromatin binding is modulated by purine levels, we performed BRD4 ChIP-seq in cells with SLC nucleoside transporters knockout, or cells with de novo purine synthesis inhibitor 6-MP treatment. (+)-JQ1, an inhibitor which disrupts BRD4 and acetylated histone binding, was used as a positive control.

ORGANISM(S): Homo sapiens

PROVIDER: GSE167374 | GEO | 2021/04/17

REPOSITORIES: GEO

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