SARS-CoV-2 spike protein interacts with and activates TLR4
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ABSTRACT: We here identified that the trimeric spike protein of SARS-CoV-2 could bind to TLR4 directly and robustly activate downstream signaling in monocytes and neutrophils. Moreover, specific TLR4 or NFKB inhibitor, or knockout of MyD88 could significantly block IL-1B induction by spike protein. We thus reveal that spike protein of SARS-CoV-2 functions as a potent stimulus causing TLR4 activation and sepsis related abnormal responses.
ORGANISM(S): Homo sapiens
PROVIDER: GSE167480 | GEO | 2021/02/25
REPOSITORIES: GEO
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