Transcriptomics

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Bulk RNA-Seq of human primordial germ cells induced from human induced pluripotent cells


ABSTRACT: Mammalian germ cells first establish as primordial germ cells (PGCs). There is an increasing demand to investigate the characteristics of human germ cells including PGCs. Recent studies have established the methodologies to derive human germ cells such as PGCs from human induced pluripotent cells (iPSCs). The in vitro-derived PGCs are referred to as PGC-like cells (PGCLCs) and exhibit the characteristics of the PGCs immediately after specification. Here we performed bulk RNA-sequencing (RNA-Seq) of PGCLCs and their parental iPSCs to characterize the expression signatures of human genes and transposable elements in PGCLCs in detail.

ORGANISM(S): Homo sapiens

PROVIDER: GSE167570 | GEO | 2022/03/08

REPOSITORIES: GEO

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