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Intestine-specific activation of LXR via low-dose oral administration of GW3965

ABSTRACT: Generation of high density lipoprotein (HDL) requires apoA1 and the cholesterol transporter ABCA1. Although the liver generates most HDL in blood, small intestines also can synthesize HDL. However, distinct functions for intestinal HDL are unknown. Here we designed intestine-specific activation of LXR via low-dose administration of GW3965, LXR agonist. The liver status was improved by therapeutics that elevated and depended upon intestinal HDL production via GW3965. Thus, protection of the liver from injury in response to gut-derived signals like LPS is a major function of intestinally synthesized HDL.

ORGANISM(S): Mus musculus

PROVIDER: GSE167983 | GEO | 2021/10/06

REPOSITORIES: GEO

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