Transcriptomics

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RNA-Seq of M1 activated ErbB4-null and WT bone-marrow macrophages.


ABSTRACT: We tested the hypothesis that NRG4/ErbB4 signaling regulates cytokine production in macrophages. Loss of ErbB4 in bone-marrow derived macrophages results in elevated pro-inflammatory cytokine production. These results demonstrate a feedback mechanism by which growth factor signaling can limit immune cells activity.

ORGANISM(S): Mus musculus

PROVIDER: GSE168070 | GEO | 2021/04/09

REPOSITORIES: GEO

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