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DNA binding profile of c-FOS in experimentally-induced basal to squamous cell carcinoma transition (BST)

ABSTRACT: Basal cell carcinoma may undergo BST spontaneously or upon Hedgehog targeting therapy. We identified that modulation of Ras/MAPK or TGFb signaling drive BST. Here, we induce Ras/MAPK and/or abrogate TGFb signaling to induce BST and examine the DNA binding profile of the AP-1 transcription factor c-FOS.

ORGANISM(S): Mus musculus

PROVIDER: GSE168374 | GEO | 2021/10/20

REPOSITORIES: GEO

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