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RNA-Seq of genetically engineered mouse model of Epithelioid Hemangioendothelioma tumors

ABSTRACT: Epithelioid hemangioendothelioma (EHE) is a rare vascular sarcoma that is associated with a WWTR1-CAMTA1 fusion gene in greater than 90% of cases. Using an adaptation of the FLEx system, we generated a genetically engineered mouse model of EHE whereby the endogenous Wwtr1 Locus is replaced with an Wwtr1-Camta1 locus. RNA was isolated from the resultant tumors and from control liver tissue and RNA sequencing was performed. Cross species analysis between human and mice tumors demonstrated murine EHE maintains the defining transcriptional features of human EHE.

ORGANISM(S): Mus musculus

PROVIDER: GSE168494 | GEO | 2021/03/25

REPOSITORIES: GEO

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