Stromal inflammation is a targetable driver of hematopoietic aging [droplet-based scRNAseq]
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ABSTRACT: To investigate global changes in the structure of the bone marrow niche with age, we performed droplet-based scRNAseq (10X Genomics) of unfractionated endosteal and central marrow stromal cells (Ter119-/CD45-). 8,735 cells passed QC, and hematopoietic clusters of cells were excluded based on marker gene expression, leaving 2359 cells distributed across 9 distinct clusters for final presentation.
ORGANISM(S): Mus musculus
PROVIDER: GSE168586 | GEO | 2022/11/02
REPOSITORIES: GEO
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