Transcriptomics

Dataset Information

0

ScRNAseq of Antigen Presenting Cells in severe COVID-19 patients


ABSTRACT: We isolated PBMC from healthy, moderate ( Oxygen supply < 10L/min), and severe (Oxygen supply >= 10L/min) COVID-19 patients after their admission to Intensive Care Units (ICU), at two timepoints (Day-1 and Day-4); and performed both CD14+ Monocyte enrichment followed by a Pan-DC kit to retrieve all Antigen Presenting Cell (APC) subsets from these age-matched patients. We performed single cell RNA sequencing using 10X technology on the single cell suspensions and constracted a high-resolution map of 81,643 Antigen Presenting Cells (APC) from the three COVID-19 severity groups. We were able to retrieve all the known six APC subsets and deciphered the altered pathways and ati-viral mechanisms, correlated with the disease severity.

ORGANISM(S): Homo sapiens

PROVIDER: GSE169346 | GEO | 2021/05/10

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2021-05-31 | GSE174818 | GEO
2022-02-22 | PXD023175 | Pride
2022-12-18 | GSE221234 | GEO
2022-07-19 | E-MTAB-10926 | biostudies-arrayexpress
2022-03-01 | E-MTAB-10970 | biostudies-arrayexpress
| PRJNA912320 | ENA
2024-01-16 | GSE222471 | GEO
2021-06-25 | GSE178824 | GEO
2022-02-01 | E-MTAB-10129 | biostudies-arrayexpress
2023-01-11 | GSE212584 | GEO