Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

BeadChip microarray data of peripheral blood obtained from treatment-näive IBD patients and control individuals

ABSTRACT: Comperhensive analysis of blood transcriptomes obtained from treatment-näive IBD patients.

ORGANISM(S): Homo sapiens

PROVIDER: GSE169568 | GEO | 2022/08/16

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Small RNA-seq data of peripheral blood obtained from treatment-näive IBD patients and control individuals (small RNA-Seq I)

Project description:Comperhensive analysis of blood transcriptomes obtained from treatment-näive IBD patients.

2022-08-16 | GSE169569 | GEO

Small RNA-seq data of peripheral blood obtained from treatment-receiving IBD patients and control individuals (small RNA-Seq II)

Project description:Comperhensive analysis of blood transcriptomes obtained from treatment-receiving IBD patients.

2022-08-16 | GSE169570 | GEO

BeadChip microarray data of peripheral blood obtained from treatment-näive IBD patients and control individuals

Project description:BeadChip microarray data of peripheral blood obtained from treatment-näive IBD patients and control individuals

| PRJNA717021 | ENA

Small RNA-seq data of peripheral blood obtained from treatment-näive IBD patients and control individuals (small RNA-Seq I)

Project description:Small RNA-seq data of peripheral blood obtained from treatment-näive IBD patients and control individuals (small RNA-Seq I)

| PRJNA717018 | ENA

Small RNA-seq data of peripheral blood obtained from treatment-receiving IBD patients and control individuals (small RNA-Seq II)

Project description:Small RNA-seq data of peripheral blood obtained from treatment-receiving IBD patients and control individuals (small RNA-Seq II)

| PRJNA717025 | ENA

Low mass blood peptides discriminative of IBD severity

Project description:The enriched low mass proteome is unexplored as a source of differentiators for diagnosing and monitoring Inflammatory Bowel Disease (IBD) activity, less invasively than colonoscopy and histopathology. Differences in the enriched low mass plasma proteome (<25kDa) were assessed by label-free quantitative mass-spectrometry. A panel of marker candidates were progressed to validation phase and ‘Tier-2’ FDA-level validated quantitative assay. Proteins important in maintaining gut barrier function and homeostasis at the epithelial interface have been quantitated by Multiple Reaction Monitoring (MRM) in plasma and serum including both inflammatory rheumatoid arthritis controls (RA) and non-inflammatory healthy controls (C), ulcerative colitis (UC) and crohn’s disease (CD) patients. Detection by immunoblot confirmed presence at the protein level in serum. Correlation analysis and receiver operator characteristics were used to report the sensitivity and specificity. Five peptides discriminating IBD activity and severity had very little-to-no correlation to Erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), white cell or platelet counts. Three of these peptides were found to be binding partners to SPP24 protein alongside other known matrix proteins. These Proteins have the potentially improve effective diagnosis and evaluate IBD activity, reducing the need for more invasive techniques.

2015-11-06 | PXD002821 | Pride

Whole blood expression profiling of patients with inflammatory bowel diseases in IBD-Character cohort

Project description:The IBD-Character cohort (Edinburgh, Oslo, Örebro, Linköping, Zaragoza, Maastricht) included patients with inflammatory bowel diseases (IBD: Crohn's disease, ulcerative colitis) recruited at diagnosis and non-IBD controls. Paired-end RNA sequencing was used for whole blood expression profiling. Raw and normalized counts tables are provided.

2022-03-01 | E-MTAB-11349 | biostudies-arrayexpress

Pediatric IBD MLI metaproteomics

Project description:Mucosal-luminal interface (MLI) samples were collected from a cohort of children with new-onset IBD and microbial cells were harvested and processed for metaproteomic analysis. Deep metaproteomics data analysis was then performed for better understanding the MLI microbiota functions in the development of pediatric IBD.

2018-08-03 | PXD007819 | Pride

Human macrophage responses to viral-like particles from non-IBD or IBD colonic resections

Project description:Peripheral blood-derived macrophages were stimulated with viral-like particles isolated from colonic resections from patients with Crohn's disease (CD), ulcerative colitis (UC), or non-IBD controls diagnoses. RNAseq was performed to unbiasedly assess the transcriptional responses to these stimuli and revealed highly divergent macrophage transcriptional programs in response to non-IBD compared to IBD VLP.

2020-06-01 | GSE135223 | GEO

IBD virome

Project description:IBD virome Raw sequence reads

| PRJNA552463 | ENA