Transcriptomics

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Fibroblast pyruvate carboxylase is required for collagen production in the tumor microenvironment


ABSTRACT: The aberrant production of collagen by fibroblasts is a hallmark of many solid tumors and can influence cancer progression. How fibroblasts produce collagen within tumor microenvironments which are nutrient-poor is not understood. Here, we show that pyruvate carboxylase (PC) activity increases in fibroblasts cultured in a low glutamine environment, and that PC is required for collagen production by tumor-associated fibroblasts in vivo.

ORGANISM(S): Mus musculus

PROVIDER: GSE169588 | GEO | 2021/09/03

REPOSITORIES: GEO

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