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Age-related gene expression changes in seeded tauopathy

ABSTRACT: Wildtype mice at either 3 or 12 months old were subjected to intrahippocampal injection with sarkosyl insoluble brain extracts from either human control or Alzheimer's disease brain. Mice were incubated for 1, 3 or 5 months and then sacrificed. The hippocampus from one hemisphere was used to extract total RNA that was then subjected to polyA-selection and whole transcriptome sequencing. 3 and 12 month old animals were processed in seperate batches and comparisons between control and Alzheimer's disease injected animals from each timepoint were conducted

ORGANISM(S): Mus musculus

PROVIDER: GSE169686 | GEO | 2021/08/31

REPOSITORIES: GEO

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