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Slic-seq for A-to-I edited transcripts enrichment


ABSTRACT: Adenosine-to-inosine (A-to-I) RNA editing is a post-transcriptional processing event involved in diversifying the transcriptome responsible for various biological processes. In this context, we developed a new biochemical method that enriches the inosine-containing RNA. The objective is the accurate identification of A-to-I editing sites, eliminating false positives caused by RNA-DNA differences. This method was applied to three neurological diseases, demonstrating that A-to-I editing sites significantly decreased in neuronal activity genes.

ORGANISM(S): Mus musculus Homo sapiens

PROVIDER: GSE169710 | GEO | 2021/03/27

REPOSITORIES: GEO

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