Transcriptomics

Dataset Information

0

Retinal gene expression in Egr-1 knock-out mice during development (p30 and p42)


ABSTRACT: In chicks, the avian homologue of the early growth response protein-1 (ZENK) has been shown to be increased in a special cell type of the retina, the glucagonergic amacrine cells, under conditions that lead to a reduction in eye growth (myopic defocus, recovery of myopia) and decreased under conditions that enhance ocular growth (hyperopic defocus, form-deprivation). The investigation of Egr-1 knock-out mice showed that homozygous knock-out mice with no functional Egr-1 protein developed relative axial myopia at the age of 42 and 56 days, compared to heterozygous- and wildtype Egr-1 knock-out mice. To clarify the role of Egr-1 in the retinal regulation of eye growth, and to get an idea about the biochemical pathways underlying this mechanism, we studied the role of Egr-1 in more detail using Affymetrix microarrays.

ORGANISM(S): Mus musculus

PROVIDER: GSE16974 | GEO | 2009/11/30

SECONDARY ACCESSION(S): PRJNA117269

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2009-12-14 | E-GEOD-16974 | biostudies-arrayexpress
2021-06-03 | GSE158732 | GEO
2014-12-31 | GSE58124 | GEO
2008-11-01 | E-MEXP-1698 | biostudies-arrayexpress
2006-02-27 | GSE3300 | GEO
2017-02-09 | GSE84220 | GEO
2024-05-08 | GSE223434 | GEO
2010-07-01 | E-GEOD-3300 | biostudies-arrayexpress
2009-11-30 | GSE18913 | GEO
2021-12-15 | GSE142359 | GEO