Genomics

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MiRNA expression in adipose tissue and liver from a spontaneous rat model of Type 2 diabetes


ABSTRACT: MicroRNAs (miRNAs) are non-coding RNA molecules involved in post-transcriptional control of gene expression of a wide number of genes, including those involved in glucose homeostasis. Type 2 diabetes (T2D) is characterized by hyperglycaemia and defects in insulin secretion and action at target tissues. Using a miRNA microarray platform, we sought to establish differences in miRNA expression in two insulin-target tissues (liver and adipose tissue) from seven-month-old spontaneously diabetic (Goto-Kakizaki [GK]) and non-diabetic (Brown-Norway [BN]) rats. MiRNA data were integrated with gene expression data from the same rats to investigate how differentially expressed miRNAs affected the expression of their predicted target genes.

ORGANISM(S): Mus musculus Rattus norvegicus Homo sapiens

PROVIDER: GSE17058 | GEO | 2009/07/14

SECONDARY ACCESSION(S): PRJNA123439

REPOSITORIES: GEO

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