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Geographical Genomics of Human Leukocytes Gene Expression Variation

ABSTRACT: Genome-wide association studies of transcript abundance in peripheral blood samples or derivative cell lines have demonstrated a preponderance of eSNP effects that, for the most part, involve regulatory polymorphisms in the differentially expressed gene. Several of these highlight associations that contribute to a variety of disease conditions, but the question arises as to how the associations are affected by the environment. Here we address the robustness of eSNP associations to environmental geography and population structure in a comparison of 194 Arab and Amazigh individuals from a city and two villages in southern Morocco.

ORGANISM(S): Homo sapiens

PROVIDER: GSE17065 | GEO | 2009/12/01

SECONDARY ACCESSION(S): PRJNA119845

REPOSITORIES: GEO

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