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Transcriptomic changes associated with CCN2/CTGF deficiency in the mouse embryonic retina

ABSTRACT: The cellular communication network (CCN) 2, also known as CTGF, is a secreted matricellular protein with regulatory functions in vasoproliferative and fibrotic diseases. Although CCN2 functions extend to developmental processes, the impact of CCN2/CTGF expression, or lack thereof, during retinogenesis is unknown. Herein, we used bulk RNA-sequencing to determine the transcriptomic changes associated with global deletion of CCN2 in E18.5 mouse retinas. we show that CCN2 signals act on intrinsic signal transduction pathway genes and induce genetic reprogramming of retinal progenitor cells endowing these cells with neurogenic and gliogenic potentials.

ORGANISM(S): Mus musculus

PROVIDER: GSE171232 | GEO | 2022/04/01

REPOSITORIES: GEO

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Transcriptomic changes associated with CCN2/CTGF deficiency in the mouse embryonic retina

Project description:Transcriptomic changes associated with CCN2/CTGF deficiency in the mouse embryonic retina

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Transcriptional effects of CTGF inhibition and gemcitabine in the KPC mouse model of pancreatic ductal adenocarcinoma

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Transcriptional effects of CTGF inhibition and gemcitabine in the KPC mouse model of pancreatic ductal adenocarcinoma

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Whole-genome microarray analysis of human skin fibroblasts

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Whole-genome microarray analysis of human skin fibroblasts

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2016-04-14 | E-GEOD-69447 | biostudies-arrayexpress

CCN2 deficiency in smooth muscle cells triggers cell reprogramming and aggravates aneurysm development

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CCN2-MAPK-Id-1 Loop Feedback Amplification is involved in Maintaining Stemness in Oxaliplatin-resistant Hepatocellular Carcinoma

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