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A translation control module coordinates germline stem cell differentiation with ribosome biogenesis during Drosophila oogenesis

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Drosophila melanogaster

PROVIDER: GSE171350 | GEO | 2022/03/24

REPOSITORIES: GEO

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A translation control module coordinates germline stem cell differentiation with ribosome biogenesis during Drosophila oogenesis [Polysome-seq]

Project description:Ribosomal defects perturb stem cell differentiation, causing diseases called ribosomopathies. How ribosome levels control stem cell differentiation is not fully known. Here, we discovered three RNA helicases are required for ribosome biogenesis and for Drosophila oogenesis. Loss of these helicases, which we named Aramis, Athos and Porthos, lead to aberrant stabilization of p53, cell cycle arrest and stalled GSC differentiation. Unexpectedly, Aramis is required for efficient translation of a cohort of mRNAs containing a 5’-Terminal-Oligo-Pyrimidine (TOP)-motif, including mRNAs that encode ribosomal proteins and a conserved p53 inhibitor, Novel Nucleolar protein 1 (Non1). The TOP-motif co-regulates the translation of growth-related mRNAs in mammals. As in mammals, the La-related protein co-regulates the translation of TOP-motif containing RNAs during Drosophila oogenesis. Thus, a previously unappreciated TOP-motif in Drosophila responds to reduced ribosome biogenesis to co-regulate the translation of ribosomal proteins and a p53 repressor, thus coupling ribosome biogenesis to GSC differentiation.

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A translation control module coordinates germline stem cell differentiation with ribosome biogenesis during Drosophila oogenesis [mRNA_RIP-seq]

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A translation control module coordinates germline stem cell differentiation with ribosome biogenesis during Drosophila oogenesis [rRNA_RIP-seq]

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A translation control module coordinates germline stem cell differentiation with ribosome biogenesis during Drosophila oogenesis [RNA-seq]

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A translation control module coordinates germline stem cell differentiation with ribosome biogenesis during Drosophila oogenesis [aramis mRNA IP]

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A translation control module coordinates germline stem cell differentiation with ribosome biogenesis during Drosophila oogenesis [bam-aramis double mRNAseq]

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A translation control module coordinates germline stem cell differentiation with ribosome biogenesis during Drosophila oogenesis

Project description:A translation control module coordinates germline stem cell differentiation with ribosome biogenesis during Drosophila oogenesis

| PRJNA719154 | ENA

A translation control module coordinates germline stem cell differentiation with ribosome biogenesis during Drosophila oogenesis [Polysome-seq]

Project description:A translation control module coordinates germline stem cell differentiation with ribosome biogenesis during Drosophila oogenesis [Polysome-seq]

| PRJNA719159 | ENA

A translation control module coordinates germline stem cell differentiation with ribosome biogenesis during Drosophila oogenesis [rRNA_RIP-seq]

Project description:A translation control module coordinates germline stem cell differentiation with ribosome biogenesis during Drosophila oogenesis [rRNA_RIP-seq]

| PRJNA719156 | ENA

A translation control module coordinates germline stem cell differentiation with ribosome biogenesis during Drosophila oogenesis [mRNA_RIP-seq]

Project description:A translation control module coordinates germline stem cell differentiation with ribosome biogenesis during Drosophila oogenesis [mRNA_RIP-seq]

| PRJNA719157 | ENA

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