Targeting SWI/SNF ATPases in enhancer-addicted prostate cancer [HiChIP-Seq]
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ABSTRACT: This study profiles chromatin accessibility, gene expresison, transcription factor binding, and three-dimensional DNA-DNA contact changes upon rapid SWI/SNF ATPase inactivation in prostate cancer cells. SWI/SNF ATPases activity was disabled using a novel PROTAC degrader compound targeting the SMARCA2, SMARCA4 and PBRM1 subunits of the SWI/SNF remodeling complex.
ORGANISM(S): Homo sapiens
PROVIDER: GSE171591 | GEO | 2021/10/28
REPOSITORIES: GEO
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