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Effect of Epstein-Barr Virus DNA on the Transcriptional Profile of BALB/c Mouse Peripheral Blood Mononuclear Cells

ABSTRACT: To examine the effect of DNA from the Epstein-Barr Virus (EBV) on the transcriptional profile of mouse peripheral blood mononuclear cells (PBMCs), BALB/c mouse cells were isolated and cultured in the presence or absence of EBV DNA. RNA was extracted from these cells and then subjected to sequencing. We observed significantly enhanced expression of genes that play roles in proinflammatory processes including ones involved in autoimmune diseases such as rheumatoid arthritis.

ORGANISM(S): Mus musculus

PROVIDER: GSE171757 | GEO | 2024/04/09

REPOSITORIES: GEO

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