Human blastocyst model by self-organization of naïve pluripotent stem cells

ABSTRACT: Human naïve pluripotent cells can differentiate to extraembryonic trophoblast and hypoblast cells. Here we report formation of human blastocyst models by self-organization solely of naïve pluripotent stem cells. The embryo models comprise the three founding lineages, epiblast, trophoblast and hypoblast, arranged to mimic the natural blastocyst. Single-cell RNA sequencing validated the identity of each cell type.

ORGANISM(S): Homo sapiens

PROVIDER: GSE171820 | GEO | 2021/05/05

REPOSITORIES: GEO