Transcriptomics

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Tumor microbiome contributes to an aggressive phenotype in the basal-like subtype of pancreatic cancer


ABSTRACT: Despite the uniform mortality in pancreatic adenocarcinoma (PDAC), clinical disease heterogeneity exists with limited genomic differences. A highly aggressive tumor subtype termed basal-like was identified to show worse outcomes and higher inflammatory responses. Here, we focus on the microbial effect in PDAC progression and present a comprehensive analysis of the tumor microbiome in different PDAC subtypes. Tumors from 62 resectable PDAC patients were subjected to metagenomic sequencing and RNA-seq.

ORGANISM(S): Homo sapiens

PROVIDER: GSE172356 | GEO | 2021/08/30

REPOSITORIES: GEO

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