Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Combination treatment with BMI1 and MAPK/ERK inhibitors is effective in medulloblastoma

ABSTRACT: Epigenetic changes play a key role in the pathogenesis of medulloblastoma (MB), the most common malignant pediatric brain tumor. Here we identify a synergic vulnerability of BMI1High;CHD7Low MB cells to a combination treatment with BMI1 and MAPK/ERK inhibitors and we elucidate the molecular mechanisms underpinning the CHD7-BMI1-MAPK regulatory axis which mediates the anti-tumor effect of these inhibitors in vitro and in vivo, in a pre-clinical mouse model. Enhanced ERK1 and ERK2 phosphorylation activity is found in BMI1High;CHD7Low G4 MB patients, raising the possibility that they could be amenable to a similar therapy.

ORGANISM(S): Homo sapiens

PROVIDER: GSE172363 | GEO | 2022/02/28

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Similar Datasets

Convergence of BMI1 and CHD7 on ERK signalling in medulloblastoma

Project description:We describe a novel molecular convergence between BMI1 and CHD7 in the initiation of medulloblastoma. We show that CHD7 controls differentiation of G4 MB cells and its silencing renders them susceptible to Bmi1-mediated ERK1/2-induced proliferation control. We show that BMI1-mediated repression of the ERK1/2 inhibitor DUSP4 leads to increased proliferation and tumour burden in primary human MB cells.

2019-06-23 | GSE83696 | GEO

Combination treatment with BMI1 and MAPK/ERK inhibitors is effective in medulloblastoma

Project description:Combination treatment with BMI1 and MAPK/ERK inhibitors is effective in medulloblastoma

| PRJNA723029 | ENA

Elucidation of BMI1, RYBP and H2AK119ub interactomes in Glioblastoma

Project description:Identification of BMI1, RYBP and H2AK119UB interactome in Glioblastoma (GBM) to elucidate BMI1 roles independent of the PRC1-complex in GBM.

2021-09-09 | PXD022057 | Pride

Murine Proerythroblasts (ProEs): WT vs. Bmi1-/-

Project description:Transcriptional profiling of ProEs purified from wild type and Bmi1-/- mice. Two-condition experiment, WT vs. Bmi1-/- ProEs. Biological replicates: 3 WT replicates, 3 Bmi1-/- replicates.

2014-11-18 | E-GEOD-63413 | biostudies-arrayexpress

Gene expression in the liver of Bmi1 knockout mice

Project description:To explore the potential targets of Bmi1 in the liver development of hepatic carcinogenesis, we assayed the gene expression level in the liver of Bmi1 knockout mice. We isolated the liver tissue of Bmi1 WT and KO mice around 6-8 weeks. Then we extracted total RNA and run the microarray detection. Gene expression in Bmi1 KO mouse livers was compared with that in Bmi1 WT mouse livers to screen potential targets of Bmi1.

2018-03-29 | GSE97170 | GEO

Bmi1 mutant vs. WT dental epithelia

Project description:Transcriptional profiling of Bmi1 mutant dental epithelia including the stem cell compartment to determine which genes are upregulated in response to loss of Bmi1.

2013-04-12 | GSE45999 | GEO

Bmi1 mutant vs. WT dental epithelia

Project description:Transcriptional profiling of Bmi1 mutant dental epithelia including the stem cell compartment to determine which genes are upregulated in response to loss of Bmi1. Two condition experiment: dental epithelia homozygous null for Bmi1 and WT dental epithelia. 4 replicates each

2013-04-12 | E-GEOD-45999 | biostudies-arrayexpress

Gene expression in the Bmi1 knockout Huh7 and Hep3B cells

Project description:Bmi1 plays a pivotal role in hepatic carcinoma (HCC), but its targets in HCC is unknown. To screen the potential targets, we transfected HCC cell line Huh7 and Hep3B with Bmi1 shRNA lenti-virus. After confirming the Bmi1 was knocked down using western blotting, we extracted total RNA and then run the microarray detection. Gene expression profiles in Bmi1 KO cells were compared with those in Bmi1 WT cells to screen potential targets of Bmi1.

2018-03-29 | GSE97169 | GEO

Murine Myeloid-Erythroid Progenitors (MEPs): WT vs. Bmi1-/-

Project description:Transcriptional profiling of MEPs purified from wild type and Bmi1-/- mice. Two-condition experiment, WT vs. Bmi1-/- MEPs. Biological replicates: 3 WT replicates, 3 Bmi1-/- replicates.

2014-11-18 | E-GEOD-63411 | biostudies-arrayexpress

Transcriptome profiling of Bmi1 silenced-K562 CML cell line

Project description:The Bmi1 Polycomb protein is involved in the epigenetic repressive control of self renewal and survival of cancer initiating cells. In Chronic Myeloid Leukemia (CML), bmi1 expression increases gradually as the disease progresses from a chronic latent phase to a deadly blast crisis. We developped an inducible shRNA system to silence Bmi1 in the human K562 chronic myeloid leukemia (CML) cell line in order to identify new Bmi1-target genes.

2015-05-12 | GSE54262 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data