Loss of retinoic acid signaling drives immune escape in IDH mutant gliomas

ABSTRACT: Gliomas are immunologically cold tumors that can be broken into several categories based on either RNA expression profiles or methylation profiles, with isocitrate dehydrogenase (IDH) mutations defining a major segregration between types. IDH mutant gliomas often exhibit defects in the retinoic acid pathway. We treated mice harboring IDH mutant gliomas with all-trans retinoic acid, and found that this treatment cause reductions in tumor growth and a swith in immune profiles in the tumor microenvironment.

ORGANISM(S): Mus musculus

PROVIDER: GSE172387 | GEO | 2024/04/19

REPOSITORIES: GEO