Transcriptomics

Dataset Information

0

Expression data of Saccharomyces cerevisiae treated with clioquinol


ABSTRACT: Clioquinol (CQ or iodochlorhydroxyquin, 5-chloro-7-iodo-8-hydroxyquinoline) is a hydrophobic chelator of copper, zinc, and iron. It was extensively used as an antibiotic for the treatment of diarrhea and skin infection in the mid-1900s, but then withdrawn because it was reported to be associated with subacute myelo-optic neuropathy (SMON) in Japan. Interest in this drug was recently revived as it was shown that CQ specifically kills cancer cells and significantly decreases Aβ level. Nevertheless, the underlying mechanisms of CQ’s drug effects and side effects are still unclear. We used yeast, Saccharomyces cerevisiae, as a model to study how CQ affects molecular and cellular functions. Genechip analysis was utilized to examine the effect of CQ on gene expression at the genomic level.

ORGANISM(S): Saccharomyces cerevisiae Schizosaccharomyces pombe

PROVIDER: GSE17257 | GEO | 2010/05/21

SECONDARY ACCESSION(S): PRJNA118941

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2010-06-08 | E-GEOD-17257 | biostudies-arrayexpress
2012-10-01 | E-GEOD-32173 | biostudies-arrayexpress
2012-10-01 | GSE32173 | GEO
2022-05-25 | GSE176379 | GEO
2022-05-25 | GSE176557 | GEO
2011-09-15 | E-GEOD-32157 | biostudies-arrayexpress
2011-09-16 | GSE32157 | GEO
| PRJNA147633 | ENA
| PRJNA736037 | ENA
2017-07-18 | GSE99884 | GEO