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Analysis of the DNA topology upon multiple histone H1 variants depletion by Hi-C experiments

ABSTRACT: The combined depletion of histones H1.2 and H1.4 in T47D-MTVL human breast cancer cells has a strong deleterious effect, deregulates gene expression, promotes the appearance of genome-wide accessibility sites, and triggers the interferon response. We have further analyzed the consequences of multiple H1 variants depletion at the topological level by performing Hi-C experiments on T47D-MTVL cancer cells expressing a Dox-inducible shRNA against multiple H1 variants.

ORGANISM(S): Homo sapiens

PROVIDER: GSE172618 | GEO | 2022/03/23

REPOSITORIES: GEO

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Project description:Genome-wide profiling of histone H1 variants and H3K9me3 in T47D-MTVL cells upon multiple H1 depletion

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