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Single cell RNA-Seq analysis of A20 tumors derived from tumor-bearing Balb/c mice treated with vehicle or 7.5 mg/kg TAK-981 for 8 h demonstrates induction of IFN1 gene expression in monocytes and T-cells

ABSTRACT: Single cell RNA-Seq analysis of A20 tumors indicated that the IFN1 signature was derived primarily from monocytes and T cells, not the B cell population which includes A20 tumor cells. Single cell RNA-Seq analysis characterized the effect of TAK-981 on B cells (n=4513, includes both A20 B lymphoma tumor cells and WT B cells), erythrocytes (n=238), monocytes (n=85) and T cells (n=107) from A20 tumors responding to treatment with TAK-981. Tumors were harvested 8 h after treatment of A20 tumor-bearing Balb/c mice with either vehicle or 7.5 mg/kg TAK-981 and subjected to scRNA-Seq.

ORGANISM(S): Mus musculus

PROVIDER: GSE173117 | GEO | 2021/04/23

REPOSITORIES: GEO

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Activation of IFN1 signaling by TAK-981 in blood, spleen, or tumor of A20-tumor bearing or B16F10-tumor bearing mice

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Most cancer cell lines give very modest transcriptional regulation following treatment with the SUMO activating enzyme inhibitors TAK-981 or ML-792

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