Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

CNO stimulated hM3Dq-expressing iPS cell-derived neural cells

ABSTRACT: hM3Dq-expressing iPS cell-derived neural cells were stimulated by CNO treatment for two hours. Comparing to the vehicle-treated control, enhanced expressions of immediate early genes were observed.

ORGANISM(S): Homo sapiens

PROVIDER: GSE173243 | GEO | 2021/11/23

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

CNO stimulated hM3Dq-expressing iPS cell-derived neural cells

Project description:CNO stimulated hM3Dq-expressing iPS cell-derived neural cells

| PRJNA724871 | ENA

Mouse spinal cords transplanted with human iPS cell-derived neural cells with and without chemogenetic stimulations on 14-days and 42-days after spinal cord injury.

Project description:hM3Dq-expressing human iPS cell-derived neural cells were transplanted in the injured mouse spinal cord. Thereafter, transplanted cells were selectively stimulated daily by intraperitoneal injection of CNO. The spinal cord 14-days and 42-days after the injury were eviscerated for analyses.

2021-11-23 | GSE173244 | GEO

Chronic, Chemogenetic Stimulation of The Nucleus Accumbens Produces Lasting Effects on Binge Drinking and Ameliorates Alcohol-Related Transcriptional and Morphological Changes

Project description:We report RNA-Seq data obtained from nucleus accumbens tissue of HDID-1 mice subjected to chronic stimulation via CNO/DREADDs within a Drinking in The Dark (DID) Paradigm. Here, we found that chronically increasing NAc activity (via CNO/hM3Dq) decreased binge-like drinking, an effect lasting for at least 7 days . CNO did not alter intake in hM4Di- or GFP-expressing mice. We observed interesting and significant changes in expression of several plasticity-related genes (e.g. Hdac4 was increased with binge drinking, and ameliorated with CNO).

2019-06-21 | GSE133115 | GEO

Human corneal endothelial cells, iPS cells, CECSi cells, and neural crest cells

Project description:Transcriptional profiling of human iPS cells, CECSi cells and iPS-derived neural crest cells (NCC) comparing human corneal endothelial cells (HCE)

2021-06-18 | GSE178434 | GEO

Modeling SARS-CoV-2 infection and its individual differences with ACE2-expressing human iPS cells

Project description:Genetic differences are a primary reason for differences in the susceptibility and severity of COVID-19. As induced pluripotent stem (iPS) cells maintain the genetic information of the donor, they can be used to model individual differences in SARS-CoV-2 infection in vitro. We found that human iPS cells expressing the SARS-CoV-2 receptor angiotensin-converting enzyme 2 (ACE2) (ACE2-iPS cells) can be infected w SARS-CoV-2. In infected ACE2-iPS cells, the expression of SARS-CoV-2 nucleocapsid protein, budding of viral particles, and production of progeny virus, double membrane spherules, and double-membrane vesicles were confirmed. We performed SARS-CoV-2 infection experiments on ACE2-iPS/ embryonic stem (ES) cells from eight individuals. Male iPS/ES cells were more capable of producing the virus compared with female iPS/ES cells. These findings suggest that ACE2-iPS cells can not only reproduce individual differences in SARS-CoV-2 infection in vitro but also are a useful resource to clarify the causes of individual differences in COVID-19 due to genetic differences.

2021-04-18 | GSE166990 | GEO

LEOPARD Syndrome iPS, BJ iPS and Fibroblasts

Project description:Expression data from LEOPARD Syndrome-iPS clones, BJ-iPS cells and parental Fibroblasts

2010-06-10 | GSE20473 | GEO

Genome-wide nucleosome positioning maps from undifferentiated human iPS cells (hIPS) and iPS cells differentiated to neural progenitor cells (NPC).

Project description:We report the application of MNase-seq (Kent, Adams et al. 2011) to construct genome-wide nucleosome maps from human cells. To date, genome-wide changes in chromatin structure that occur during development in human cells have not been investigated widely. We have constructed and compared genome-wide chromatin maps from undifferentiated human iPS cells and and iPS cells differentiated to neural progenitor cells (NPC).

2019-04-24 | GSE117870 | GEO

Ips calligraphus

Project description:Ips calligraphus overview

| PRJNA806287 | ENA

Ips nitidus

Project description:Ips nitidus overview

| PRJNA780645 | ENA

Ips pini

Project description:Ips pini overview

| PRJNA88143 | ENA