Transcriptomics

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BCL11B enhancer hijacking defines a subtype of lineage ambiguous stem cell leukemia [single-cell multiomics]

ABSTRACT: Hijacking of primitive hematopoietic enhancers, or generation of a neo-enhancer by genomic amplification, results in deregulation of BCL11B as the defining feature of a subset of T/myeloid leukemia. We report H3K27ac and BCL11B binding in these Leukemias.

ORGANISM(S): Homo sapiens

PROVIDER: GSE173319 | GEO | 2021/05/19

REPOSITORIES: GEO

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