Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Allele-specific differential regulation of monoallelically expressed autosomal genes in the cardiac lineage

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE173403 | GEO | 2022/08/22

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Allele-specific differential regulation of monoallelically expressed autosomal genes in the cardiac lineage (scRNA-Seq)

Project description:We reported the allele-specific single cell RNA sequencing in highly morphogenic (C57Bl6J-maternal x CASTEiJ-paternal) male F1 mouse embryonic stem cells (mESC) and in vitro mESC derived six cardiac lineage cell types. We demonstrated distinctive gene regulation based on the parental origin of the alleles. We showed that deterministic and stochastic monoalleleic gene classes are distinctive in regulation and are involved in unique processes. In this study we highlighted the importance of parental origin-specific gene expression in development, homeostasis and disease.

2022-08-22 | GSE173402 | GEO

Allele-specific differential regulation of monoallelically expressed autosomal genes in the cardiac lineage [CUT&Tag]

2022-08-22 | GSE195876 | GEO

Allele-specific differential regulation of monoallelically expressed autosomal genes in the cardiac lineage (Bulk RNA-Seq)

Project description:We reported the allele-specific bulkl RNA sequencing in highly morphogenic (C57Bl6J-maternal x CASTEiJ-paternal) male F1 mouse embryonic stem cells (mESC) and in vitro mESC derived six cardiac lineage cell types. We demonstrated distinctive gene regulation based on the parental origin of the alleles. We showed that deterministic and stochastic monoalleleic gene classes are distinctive in regulation and are involved in unique processes. In this study we highlighted the importance of parental origin-specific gene expression in development, homeostasis and disease.

2022-08-22 | GSE173400 | GEO

Allele-specific differential regulation of monoallelically expressed autosomal genes in the cardiac lineage

Project description:Allele-specific differential regulation of monoallelically expressed autosomal genes in the cardiac lineage

| PRJNA725426 | ENA

Allele-specific differential regulation of monoallelically expressed autosomal genes in the cardiac lineage (scRNA-Seq)

Project description:Allele-specific differential regulation of monoallelically expressed autosomal genes in the cardiac lineage (scRNA-Seq)

| PRJNA725445 | ENA

Allele-specific differential regulation of monoallelically expressed autosomal genes in the cardiac lineage [CUT&Tag]

Project description:Allele-specific differential regulation of monoallelically expressed autosomal genes in the cardiac lineage [CUT&Tag]

| PRJNA802532 | ENA

Allele-specific differential regulation of monoallelically expressed autosomal genes in the cardiac lineage (Bulk RNA-Seq)

Project description:Allele-specific differential regulation of monoallelically expressed autosomal genes in the cardiac lineage (Bulk RNA-Seq)

| PRJNA725423 | ENA

Differential Allele-Specific Expression Uncovers Breast Cancer Genes Dysregulated by Cis Noncoding Mutations.

Project description:Identifying cancer-relevant mutations in noncoding regions is challenging due to the large numbers of such mutations, their low levels of recurrence, and difficulties in interpreting their functional impact. To uncover genes that are dysregulated due to somatic mutations in cis, we build upon the concept of differential allele-specific expression (ASE) and introduce methods to identify genes within an individual's cancer whose ASE differs from what is found in matched normal tissue. When applied to breast cancer tumor samples, our methods detect the known allele-specific effects of copy number variation and nonsense-mediated decay. Further, genes that are found to recurrently exhibit differential ASE across samples are cancer relevant. Genes with cis mutations are enriched for differential ASE, and we find 147 potentially functional noncoding mutations cis to genes that exhibit significant differential ASE. We conclude that differential ASE is a promising means for discovering gene dysregulation due to cis noncoding mutations.

| S-EPMC7457951 | biostudies-literature

Lineage-specific regulation of epigenetic modifier genes in human liver and brain.

Project description:Despite an abundance of studies on chromatin states and dynamics, there is an astonishing dearth of information on the expression of genes responsible for regulating histone and DNA modifications. We used here a set of 156 defined epigenetic modifier genes (EMG) and profiled their expression pattern in cells of different lineages. As reference value, expression data from human embryonic stem cells (hESC) were used. Hepatocyte-like cells were generated from hESC, and their EMG expression was compared to primary human liver cells. In parallel, we generated postmitotic human neurons (Lu d6), and compared their relative EMG expression to human cortex (Ctx). Clustering analysis of all cell types showed that neuronal lineage samples grouped together (94 similarly regulated EMG), as did liver cells (61 similarly-regulated), while the two lineages were clearly distinct. The general classification was followed by detailed comparison of the major EMG groups; genes that were higher expressed in differentiated cells than in hESC included the acetyltransferase KAT2B and the methyltransferase SETD7. Neuro-specific EMGs were the histone deacetylases HDAC5 and HDAC7, and the arginine-methyltransferase PRMT8. Comparison of young (Lu d6) and more aged (Ctx) neuronal samples suggested a maturation-dependent switch in the expression of functionally homologous proteins. For instance, the ratio of the histone H3 K27 methyltransfereases, EZH1 to EZH2, was high in Ctx and low in Lu d6. The same was observed for the polycomb repressive complex 1 (PRC1) subunits CBX7 and CBX8. A large proportion of EMGs in differentiated cells was very differently expressed than in hESC, and absolute levels were significantly higher in neuronal samples than in hepatic cells. Thus, there seem to be distinct qualitative and quantitative differences in EMG expression between cell lineages.

| S-EPMC4108363 | biostudies-literature

Dynamic and Coordinated Epigenetic Regulation of Developmental Transitions in the Cardiac Lineage

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2013-06-15 | E-GEOD-47950 | biostudies-arrayexpress