Genome-wide STAT5 occupancy profiling in LPS induced CD127 expressing human monocytes

ABSTRACT: STAT5 functions in human inflammatory monocytes is largely unknown. We identified the anti-inflammatory function of CD127-STAT5 axis in human monocytes. To investigate the mechanism underlying STAT5-mediated anti-inflammatory regulation, thoroughly dissecting the STAT5 genomic distribution in human monocytes would be informative. Therefore, we performed anti-STAT5 ChIP-seq analyses for CD127high monocytes under LPS stimulation to globally characterize the STAT5 occupancy in CD127 expressing human monocytes.

ORGANISM(S): Homo sapiens

PROVIDER: GSE173490 | GEO | 2021/12/20

REPOSITORIES: GEO