Transcriptomics

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Gene expression changes associated with myocarditis and fibrosis in hearts of mice with chronic chagasic cardiomyopathy


ABSTRACT: Chronic chagasic cardiomyopathy is a leading cause of heart failure in Latin American countries. About 30% of Trypanosoma cruzi-infected individuals develop this severe symptomatic form of the disease, characterized by intense inflammatory response accompanied by fibrosis deposition in the heart. We performed a microarray analysis of a mouse model of this disease and identified >5% alterations of gene expression in the heart. Most of the upregulations were associated with immune-inflammatory responses (chemokines, adhesion molecules, cathepsins and MHC molecules) and fibrosis deposition (extracellular matrix components, lysyl oxidase and Timp1). Our results indicate potentially relevant factors involved in the pathogenesis of the disease that may provide new therapeutic targets in chronic Chagas’ disease.

ORGANISM(S): Mus musculus

PROVIDER: GSE17363 | GEO | 2009/08/07

SECONDARY ACCESSION(S): PRJNA119085

REPOSITORIES: GEO

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