Transcriptomics

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Molecular Classification of AIDS-Related Lymphomas [including third-party data]


ABSTRACT: Gene expression profiling (GEP) of ARL patient samples was done to determine whether gene expression signatures derived from HIV- lymphomas retained their ability to molecularly classify HIV+ lymphomas. The GEP-based predictors robustly classified ARL tumors, distinguishing molecular Burkitt lymphoma (BL) and diffuse large B-cell lymphoma (DLBCL), as well as activated B-cell-like (ABC) and germinal center B-cell-like (GCB) molecular subtypes of DLBCL. Gene expression profiles were used to identify coordinately regulated gene sets and pathways that differ between HIV+ and HIV- lymphomas of corresponding molecular subtype.

ORGANISM(S): Homo sapiens

PROVIDER: GSE17372 | GEO | 2012/07/18

SECONDARY ACCESSION(S): PRJNA170910

REPOSITORIES: GEO

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