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Oncogene-induced maladaptive activation of Trained Immunity in the pathogenesis of human inflammatory myeloid neoplasm [BRAF]

ABSTRACT: Trained immunity (TI) is a pro-inflammatory program induced in monocyte/macrophages upon sensing of specific pathogens and characterized by immunometabolic and epigenetic changes enhancing cytokine production. Maladaptive activation of TI (i.e., in the absence of infection) might result in detrimental inflammation and disease development; however, the exact role and extent of inappropriate activation of TI in the pathogenesis of human diseases is undetermined.

ORGANISM(S): Homo sapiens

PROVIDER: GSE173829 | GEO | 2021/05/05

REPOSITORIES: GEO

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