Genomics

Dataset Information

0

EBF1 nuclear repositioning instructs chromatin refolding to promote therapy resistance in T leukemic cells. [MB157_ChIP-seq]

ABSTRACT: Purpose: To investigate the mechanisms of 3D genome organization in drug-resistant T-ALL Methods: We used multiple epigenomics, chromatin conformation, and transcriptomic assays to study the mechanisms of chromatin adaptation in GSI-sensitive and GSI-resistant T-ALL Results: We report here that T/B cell lineage determining transcription factors are differentially expressed in GSI-resistant T-ALL cells, driving enhancer switching and genome folding reorganization events to promote GSI-resistance. Conclusions: These observations suggest a general mechanism that diffenrential activity of pioneering factors can be exploited to evade addiction to oncogenic signals.

ORGANISM(S): Homo sapiens

PROVIDER: GSE173842 | GEO | 2022/02/21

REPOSITORIES: GEO

Json Xml

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

Genomics EBF1 nuclear repositioning instructs chromatin refolding to promote therapy resistance in T leukemic cells. [DND41_ATACseq]
2022-02-21 | GSE173847 | GEO
Genomics EBF1 nuclear repositioning instructs chromatin refolding to promote therapy resistance in T leukemic cells.[MB157_ATACseq]
2022-02-21 | GSE173846 | GEO
Other EBF1 nuclear repositioning instructs chromatin refolding to promote therapy resistance in T leukemic cells.[MB157_HiChIP]
2022-02-21 | GSE173843 | GEO
Other EBF1 nuclear repositioning instructs chromatin refolding to promote therapy resistance in T leukemic cells.[DND41_4C]
2022-02-21 | GSE173866 | GEO
Other EBF1 nuclear repositioning instructs chromatin refolding to promote therapy resistance in T leukemic cells.[DND41_HiC]
2022-02-21 | GSE173864 | GEO
Other EBF1 nuclear repositioning instructs chromatin refolding to promote therapy resistance in T leukemic cells. [DND41_panel_seq]
2022-02-21 | GSE173870 | GEO
Genomics EBF1 nuclear repositioning instructs chromatin refolding to promote therapy resistance in T leukemic cells.[Granta_ATACseq]
2022-02-21 | GSE173869 | GEO
Genomics EBF1 nuclear repositioning instructs chromatin refolding to promote therapy resistance in T leukemic cells. [Jurkat_ATACseq]
2022-02-21 | GSE173868 | GEO
Other EBF1 nuclear repositioning instructs chromatin refolding to promote therapy resistance in T leukemic cells.[DND41_HiChIP]
2022-02-21 | GSE173871 | GEO
Genomics EBF1 nuclear repositioning instructs chromatin refolding to promote therapy resistance in T leukemic cells. [DND41_Cut&Run]
2022-02-21 | GSE173863 | GEO