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Reactivation of Zeta-Globin by deletion of BCL11A and LRF in murine cells

ABSTRACT: The alpha and beta-globin loci harbour genes that are expressed during development and silenced throughout post-natal life. Learning to reactivate these genes may offer new therapeutic approaches for the hemoglobinopathies, the most common single gene disorders. Here, we address the mechanisms underlying the regulation of the gene encoding zeta-globin, the embryonically expressed alpha-like globin.

ORGANISM(S): Mus musculus

PROVIDER: GSE174110 | GEO | 2021/05/09

REPOSITORIES: GEO

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