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Tim-4+ Cavity-Resident Macrophages Impair Anti-Tumor CD8+ T cell Immunity [RNA-Seq]

ABSTRACT: Here we report RNA sequencing data from sorted Tim-4low vs Tim-4high macrophages in steady-state (no tumor) mice and also MC38-LG-tumor-bearing animals that were treated with isotype or anti-Tim-4 antibody.

ORGANISM(S): Mus musculus

PROVIDER: GSE174151 | GEO | 2021/05/12

REPOSITORIES: GEO

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Tim-4+ Cavity-Resident Macrophages Impair Anti-Tumor CD8+ T cell Immunity

Project description:Tim-4+ Cavity-Resident Macrophages Impair Anti-Tumor CD8+ T cell Immunity

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Tim-4+ Cavity-Resident Macrophages Impair Anti-Tumor CD8+ T cell Immunity [scRNA-Seq]

Project description:Tim-4+ Cavity-Resident Macrophages Impair Anti-Tumor CD8+ T cell Immunity [scRNA-Seq]

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Tim-4+ Cavity-Resident Macrophages Impair Anti-Tumor CD8+ T cell Immunity

Project description:This SuperSeries is composed of the SubSeries listed below.

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Tim-4<sup>+</sup> cavity-resident macrophages impair anti-tumor CD8<sup>+</sup> T cell immunity.

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| S-EPMC9115604 | biostudies-literature

Tim-4+ Cavity-Resident Macrophages Impair Anti-Tumor CD8+ T cell Immunity [scRNA-Seq]

Project description:Here we report transcriptional and TCR specificities associated with PSlow and PShigh CD8 T cells.

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Comparative Analysis of Gene Expression in AgN2a-4P Expanded B6 NK Cells Treated with Anti-TIM-3 Antibody

Project description:Gene expression patterns in IL-15 or IL-15/AgN2a-4P expanded B6 NK cells treated with anti-TIM-3 antibody or IgG2a isotype control were analyzed using the nCounter Mouse PanCancer Immune Profiling Panel. Prior to RNA processing, NK cells were purified using the AutoMACS pro-separator (Miltenyi Biotec, San Jose, CA). The treatment involved a 4-hour exposure to antibodies before gene expression analysis, aiming to elucidate differential expression profiles in response to anti-TIM-3 treatment compared to the control condition.

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microRNA expression in Tim-3 knockdown RAW264.7 cell

Project description:RAW264.7 cell was stably transfected with Tim-3 siRNA(SI) or negative control(NC) and were analyzed for microRNA expression Differerently expressed microRNA in Tim-3 knockdown RAW264.7 cells were summarized and were used for further analysis RAW264.7 cells stably transfected with Tim-3 siRNA(SI) or negative control(NC) and were used to collect microRNA without any other treatment

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