Transcriptomics

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RNA Sequencing of npr-15(tm12539) and wild type (WT) N2 C elegans infected with Staphylococcus aureus for 8 hours


ABSTRACT: Purpose: To uncover immune genes and pathways that are modulated by the GPCR/NPR-15 during S. aureus infection Methods: RNA was extracted from synchronized L4 stage npr-15(tm12539) and WT animals grown at 20 C and infected with S. aureus for 8 hours, followed by Qiagen extraction kits and following standard methods Results: RNA seq analyses shows enriched and signficant upregulated immune, neuropeptide, synaptic signaling and metabolism genes and pathways that are dependent on NPR-15 Conclusions: Our study uncovered NPR-15 to be modulator of the innate immunity in C. elegans under infection

ORGANISM(S): Caenorhabditis elegans

PROVIDER: GSE174176 | GEO | 2024/03/04

REPOSITORIES: GEO

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