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Identification of the potential gene regulatory networks and therapeutics in aged mice with postoperative neurocognitive disorder

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE174413 | GEO | 2021/06/22

REPOSITORIES: GEO

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Identification of the Potential Gene Regulatory Networks and Therapeutics in Aged Mice With Postoperative Neurocognitive Disorder.

Project description:Postoperative neurocognitive disorder (PND) is one of the most common postoperative neurological complications in aged patients, characterized by mental disorder, anxiety, personality changes, and impaired memory. At present, the molecular mechanism of PND remains largely unclear, and the ideal biomarker for clinical diagnosis and prognosis are lacking. Circular RNA (circRNA) and microRNA (miRNA), as unique non-coding RNAs, affecting the regulation of miRNAs on genes and further intervening in the progression of diseases through the sponge action between the two. Besides, it could be served as novel biomarkers in various diseases. In order to detect the differential expression profiles of genes caused by PND, a total of 26 18-month-old male C57BL/6 mice were randomly assigned to control group and PND group. Behavioral tests showed that mice in the PND group had impaired cognitive function compared with the control group. Three mice in each group were randomly selected to harvest the brain for analysis the expressions of circRNAs, miRNAs, and mRNAs in the prefrontal cortex by next-generation sequencing (NGS) technology. Differentially expressed genes, including 1192 circRNAs, 27 miRNAs, and 266 mRNAs were identified, and its accuracy was further confirmed by qRT-PCR. Bioinformatics analysis results suggested that neuroinflammation was the main pathological mechanism of PND. The construction of competitive endogenous RNA (ceRNA) networks and the identification of hub genes provided possible therapeutic targets for PND. Cinnarizine and Clemastine were predicted to have the potential therapeutic effects on PND. This is the first study to explore the differential expression profiles of genes and their regulation mechanisms in PND, our results provided new clues and targets for the treatment of this refractory disease.

| S-EPMC8264595 | biostudies-literature

Identification of the potential gene regulatory networks and therapeutics in aged mice with postoperative neurocognitive disorder (miRNA)

Project description:Postoperative neurocognitive disorder (PND) is one of the most common postoperative neurological complications in aged patients. In order to detect the differential expression profiles of genes caused by PND, a total of 26 18-month-old male C57BL/6 mice were randomly assigned to control group and PND group. Behavioral tests showed that mice in the PND group had impaired cognitive function compared with the control group. Three mice in each group were randomly selected to harvest the brain for analysis the expressions of circRNAs, miRNAs and mRNAs in the prefrontal cortex by next-generation sequencing (NGS) technology. Differentially expressed genes, including 1192 circRNAs, 27 miRNAs and 266 mRNAs were identified, and its accuracy was further confirmed by qRT-PCR.

2021-06-23 | GSE174411 | GEO

Identification of the potential gene regulatory networks and therapeutics in aged mice with postoperative neurocognitive disorder (circRNA)

2021-06-23 | GSE174410 | GEO

Identification of the potential gene regulatory networks and therapeutics in aged mice with postoperative neurocognitive disorder (mRNA)

2021-06-23 | GSE174412 | GEO

Identification of the potential gene regulatory networks and therapeutics in aged mice with postoperative neurocognitive disorder

Project description:Identification of the potential gene regulatory networks and therapeutics in aged mice with postoperative neurocognitive disorder

| PRJNA729766 | ENA

Identification of the potential gene regulatory networks and therapeutics in aged mice with postoperative neurocognitive disorder (mRNA)

Project description:Identification of the potential gene regulatory networks and therapeutics in aged mice with postoperative neurocognitive disorder (mRNA)

| PRJNA729768 | ENA

Identification of the potential gene regulatory networks and therapeutics in aged mice with postoperative neurocognitive disorder (circRNA)

Project description:Identification of the potential gene regulatory networks and therapeutics in aged mice with postoperative neurocognitive disorder (circRNA)

| PRJNA729772 | ENA

Identification of the potential gene regulatory networks and therapeutics in aged mice with postoperative neurocognitive disorder (miRNA)

Project description:Identification of the potential gene regulatory networks and therapeutics in aged mice with postoperative neurocognitive disorder (miRNA)

| PRJNA729767 | ENA

Identification of the Potential Key circRNAs in Aged Mice With Postoperative Delirium

Project description:Postoperative delirium (POD) is a common postoperative complication in elderly patients. The exact mechanism of POD is still unclear. In order to reveal the effect of CircRNA on POD, We analyzed the differential expression profile of circRNAs by microarray technique in hippocampus of 12-month-old mice between tibial fracture and control group.

2021-12-16 | GSE190880 | GEO

Identification and functional analysis of a potential key circRNA in aged mice with perioperative neurocognitive dysfunction

Project description:Perioperative neurocognitive dysfunction (PND) is emerging as a significant complication of surgery in elderly patients. However, the molecular mechanisms of PND are not well known. Here we applied microarray analysis to identify circular RNAs (circRNAs) in hippocampus from a mouse model of PND and control mice. Then, the dysregulated circRNAs were confirmed via quantitative real-time polymerase chain reaction (qRT-PCR). Then, Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed to probe the vital functions of dysregulated genes.

2021-08-10 | GSE165798 | GEO

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