Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Bulk RNAseq Analysis of PBMCs from metastatic breast cancer patients

ABSTRACT: The goal of this study is to analyze the blood from patients with metastatic breast cancer to examine the genome of circulating tumor cells that initate metastatic tumors.

ORGANISM(S): Homo sapiens

PROVIDER: GSE174431 | GEO | 2021/10/18

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Analysis of PBMCs from metastatic breast cancer patients

Project description:The goal of this study is to analyze the blood from patients with metastatic breast cancer to examine the genome of circulating tumor cells that initiate metastatic tumors.

2021-10-18 | GSE174461 | GEO

Bulk RNAseq Analysis of PBMCs from metastatic breast cancer patients

Project description:Bulk RNAseq Analysis of PBMCs from metastatic breast cancer patients

| PRJNA729799 | ENA

PBMCs from metastatic breast cancer patients

Project description:PBMCs from metastatic breast cancer patients

| PRJNA730015 | ENA

Investigation about Monocytes in metastatic breast cancer patients under chemotherapy +/- Avastin

Project description:The goal of this study was to determine if blood circulating monocytes of metastatic breast cancer patient would express a different activation profile compared to healthy donors, in order to use this specific changesas biomarkers to monitor then response to therapy

2017-02-09 | GSE70404 | GEO

PBMCs from metastatic breast cancer patients

Project description:This SuperSeries is composed of the SubSeries listed below.

2021-10-18 | GSE174463 | GEO

Serum proteome in metastatic breast cancer patients

Project description:We identified 967 proteins among 75 serum samples from patients with BC. Among these, 39 proteins were altered in serum samples at diagnosis, between progressors and non-progressors. Among these, 4 proteins were further altered when the progressors developed distant metastasis. In addition, within progressors, 20 proteins were altered in serum collected at diagnosis versus at the onset of metastasis. Pathway analysis showed that these proteins encoded pathways that describe metastasis, including epithelial mesenchymal transition and focal adhesion that are hallmarks of metastatic cascade.

2024-03-07 | MSV000094255 | MassIVE

T cell characteristics associated with toxicity to immune checkpoint blockade in patients with melanoma [bulk RNA-seq]

Project description:Severe immune-related adverse events (irAEs) occur in up to 60% of melanoma patients treated with immune checkpoint inhibitors (ICIs). However, it remains unknown whether a common baseline immunological state precedes irAE development. Leveraging CyTOF, single-cell RNA sequencing, bulk RNA sequencing, and T cell receptor sequencing to analyze pretreatment blood from metastatic melanoma patients treated with ICIs, we investigated cellular factors associated with severe irAE development regardless of organ system involvement. Our results demonstrate circulating T cell characteristics associated with ICI-induced toxicity, with implications for improved diagnostics and clinical management.

2022-01-13 | GSE186143 | GEO

Host CLIC4 is essential for breast cancer metastatic competence

Project description:Chloride Intracellular Channel 4 (CLIC4) expression is elevated in the stroma of many cancers. We show that CLIC4 expression is higher in breast cancers from younger women and early stage metastatic disease, portends poor prognosis, and is linked to TGF-β expression. Two murine breast cancer models with lung metastases revealed that ablation of host Clic4 nearly eliminated lung metastases without reducing primary tumor size while Clic4 null tumor cells retained metastatic capability. Thus, CLIC4 is required for host metastatic competence. Deficiencies in circulating pro-metastatic soluble factors were detected in CLIC4 deficient hosts bearing primary tumors. Necrosis and vascular abnormalities were more abundant in primary tumors from CLIC4 deficient hosts than from CLIC4 proficient control hosts. Transcriptional profiles of lungs and primary tumors prior to the onset of metastases indicated that loss of host CLIC4 enhances an inflammatory microenvironment. Thus, CLIC4 expression in human breast cancers may serve as a prognostic biomarker, and targeting host CLIC4 could reduce metastatic competence.

2022-05-25 | GSE185163 | GEO

Immunological differences between primary and metastatic breast cancer

Project description:Little is known about how the immune microenvironment of breast cancer evolves during disease progression. The goal of this project was to examine immune gene mRNA expression in primary tumors (P) and metastatic lesions (M). The expression of 730 immune-related genes was measured using the Nanostring PanCancer Immune Gene Panel.

2018-08-20 | GSE102818 | GEO

Analysis of exosomal miRNA in plasma of patients with metastatic and non-metastatic pancreatic cancer

Project description:Purpose: Analysis of exosomal miRNA in plasma of patients with metastatic and non-metastatic pancreatic cancer. To identify exosomes cargo specific miRNAs promoting cancer metastasis. Methods: We divide the plasma samples into five groups according to whether they have metastasis and undergo surgery.The five groups are Health(20),Metastasis Pre-operation and Post-operation (14),Non-metastasis Pre-operation and Post-operation(9).Then we collected the exosomes by ultracentrifugation and extracted the small RNA in each sample.Then, we analyzed the expression changes of miRNA by small RNA sequencing. Result: Different groups have different expression of small RNA. Compared with the non-metastatic group, the expression of miR-92a-3p , miR-148-3p and miR-25-3p increased in the metastatic group. Conclusion:Exosomal miRNA in pancreatic cancer patient derived plasma were analyze using Hiseq2500 sequencing technique. We identified that miR-92a-3p, miR-148-3p and miR-25-3p enriched in metastatic pancreatic cancer patient plasma derived exosomes.

2022-01-01 | GSE166799 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data