Transcriptomics

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Heading towards a dead end: the role of DND1 in germ line differentiation of human iPSCs


ABSTRACT: We knocked out DND1 in human iPSCs and analysed its role in pluripotency and differentiation. We showed that general pluripotency gene expression is not affected, but KO iPSCs differentiate less efficiently towards PGC-like cells and remaining PGCLCs show reduced expression of NANOS3 and PRDM1.

ORGANISM(S): Homo sapiens

PROVIDER: GSE174464 | GEO | 2021/10/20

REPOSITORIES: GEO

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