Transcriptome-wide profiling of thyroid hormone and adrenergic interactions in the mouse heart
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ABSTRACT: During the first weeks after birth, cardiomyocytes within the mouse heart progressively exit the cell cycle, binucleate, and lose regenerative capacity. We have determined that combined pharmacological inhibition of thyroid hormone and adrenergic signaling during postnatal development robustly enhances cardiomyocyte proliferation, retention of diploid cardiomyocytes, and functional cardiac regeneration at postnatal day 14. In this study, we perform transcriptome-wide analyses to understand the genetic pathways regulated by thyroid hormone, alpha-adreneric, and beta-adrenergic signaling - individually and in combination - that promote cardiomyocyte cell-cycle arrest and loss of cardiac regenerative potential.
ORGANISM(S): Mus musculus
PROVIDER: GSE174511 | GEO | 2021/09/22
REPOSITORIES: GEO
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