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Heterogeneity of meningeal B cells reveals a lymphopoietic niche at the CNS borders

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE174836 | GEO | 2021/06/01

REPOSITORIES: GEO

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Heterogeneity of meningeal B cells reveals a lymphopoietic niche at the CNS borders.

Project description:The meninges contain adaptive immune cells that provide immunosurveillance of the central nervous system (CNS). These cells are thought to derive from the systemic circulation. Through single-cell analyses, confocal imaging, bone marrow chimeras, and parabiosis experiments, we show that meningeal B cells derive locally from the calvaria, which harbors a bone marrow niche for hematopoiesis. B cells reach the meninges from the calvaria through specialized vascular connections. This calvarial-meningeal path of B cell development may provide the CNS with a constant supply of B cells educated by CNS antigens. Conversely, we show that a subset of antigen-experienced B cells that populate the meninges in aging mice are blood-borne. These results identify a private source for meningeal B cells, which may help maintain immune privilege within the CNS.

| S-EPMC8448524 | biostudies-literature

Heterogeneity of meningeal B cells reveals a lymphopoietic niche at the CNS borders [scRNA-seq]

Project description:The meninges contain adaptive immune cells that provide immunosurveillance of the CNS. These cells are thought to derive from the systemic circulation. Through single cell analyses, confocal 35 imaging, bone marrow chimeras and parabiosis experiments, we show that meningeal B cells derive locally from the calvaria, which harbors a bone marrow niche for hematopoiesis. B cells reach the meninges from the calvaria through specialized vascular connections. This calvaria- meningeal path of B cell development may provide the CNS with a constant supply of B cells educated by CNS antigens. Conversely, we show that a subset of antigen-experienced B cells that 40 populate the meninges in aging mice are blood-borne. These results identify a private source for meningeal B cells which may help maintain immune privilege within the CNS.

2021-06-01 | GSE174834 | GEO

Heterogeneity of meningeal B cells reveals a lymphopoietic niche at the CNS borders [scBCR-seq]

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Project description:This SuperSeries is composed of the SubSeries listed below.

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Heterogeneity of meningeal B cells reveals a lymphopoietic niche at the CNS borders

Project description:Heterogeneity of meningeal B cells reveals a lymphopoietic niche at the CNS borders

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CNS-Native Myeloid Cells Drive Immune Suppression in the Brain Metastatic Niche through Cxcl10

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Heterogeneity of meningeal B cells reveals a lymphopoietic niche at the CNS borders [scRNA-seq]

Project description:Heterogeneity of meningeal B cells reveals a lymphopoietic niche at the CNS borders [scRNA-seq]

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Heterogeneity of meningeal B cells reveals a lymphopoietic niche at the CNS borders [scBCR-seq]

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