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HOXB13 lysine 13 acetylation regulated transcriptional targets in castration-resistant prostate cancer

ABSTRACT: To understand the mechanistic role of HOXB13 lysine acetylation in CRPC development andd progression, differential gene expression analysis was performed following RNA-sequencing of the HOXB13K13A mutant versus the isogenic parental C4-2B to identify bonafide transcriptional targets of acetylated HOXB13. Chromatin remodeling and self-renewal genes were significantly impacted as a result of HOXB13-K13 mutation. These results suggested that single-site acetylation in HOXB13 is critical and may even be sufficient to promote cellular reprogramming associated with PC pathogenesis.

ORGANISM(S): Homo sapiens

PROVIDER: GSE174923 | GEO | 2022/09/22

REPOSITORIES: GEO

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HOXB13 epigenome in castration-resistant prostate cancer

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HOXB13 lysine 13 acetylation regulated transcriptional targets in castration-resistant prostate cancer

Project description:HOXB13 lysine 13 acetylation regulated transcriptional targets in castration-resistant prostate cancer

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