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Kras activation in endometrial organoids drives cellular transformation and epithelial-mesenchymal transition

ABSTRACT: We found that in KrasG12D-expressing endometrial organoids, Pten knockdown did not confer tumorigenicity, but Cdkn2a knockdown or Trp53 deletion led to the development of carcinosarcoma (CS), a rare, aggressive tumor comprising both carcinoma and sarcoma.To better characterize the pathogenesis of CS from organoids, we conducted a transcriptome analysis.

ORGANISM(S): Mus musculus

PROVIDER: GSE175512 | GEO | 2021/06/30

REPOSITORIES: GEO

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Establishment of novel murine cell lines with defined mutations for preclinical in vitro and in vivo investigations of syngeneic epithelial ovarian cancer with different histological subtypes and inflammatory profiles

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