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RNAseq transcriptome analysis of A. baumannnii MS14413 treated with PBT2, zinc and tetracycline

ABSTRACT: Acinetobacter baumannii causes high mortality in ventilator-associated pneumonia patients and antibiotic treatment is compromised in multi-drug resistant strains resistant to beta-lactams, carbapenems, cephalosporins, polymyxins and tetracyclines. Among COVID-19 patients receiving ventilator support, multi-drug resistant A. baumannii secondary infection is associated with a two-fold increase in mortality. Here we investigated the use of the 8-hydroxyquinoline ionophore PBT2 to break resistance of A. baumannii to tetracycline class antibiotics.

ORGANISM(S): Acinetobacter baumannii

PROVIDER: GSE175535 | GEO | 2021/12/17

REPOSITORIES: GEO

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