Methylation profiling

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Blood DNA methylation altered by Mycobacterium tuberculosis infection in mice


ABSTRACT: Knowing when a person was infected with Mycobacterium tuberculosis (M.tb) is critical as recent infection is the strongest clinical risk factor for progression to TB disease in immunocompetent individuals. However, time since M.tb infection is very difficult to determine in routine clinical practice. We determined whether DNA methylation patterns in the blood correlate with time since M.tb infection or exposure to develop a biomarker for recent exposure. As proof of concept, we found a DNA methylation signature that is present during early infection of mice that persists for at least 5 months post-infection.

ORGANISM(S): Mus musculus

PROVIDER: GSE175661 | GEO | 2024/05/24

REPOSITORIES: GEO

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