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Active elimination of intestinal cells drives oncogenic growth in organoids

ABSTRACT: Competitive cell-interactions play a crucial role in quality control during development and homeostasis. Here we show that cancer cells use such interactions to actively eliminate wild-type intestine cells in enteroid monolayers and organoids. This apoptosis-dependent process boosts proliferation of intestinal cancer cells. The remaining wild-type population activates markers of primitive epithelia and transits to a fetal-like state. Prevention of this cell fate transition avoids elimination of wild-type cells and, importantly, limits the proliferation of cancer cells. JNK signaling is activated in competing cells and is required for cell fate change and elimination of wild-type cells. Thus, cell competition drives growth of cancer cells by active out-competition of wild-type cells through forced cell death and cell fate change in a JNK dependent manner.

ORGANISM(S): Mus musculus

PROVIDER: GSE176027 | GEO | 2021/07/06

REPOSITORIES: GEO

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Gene expression change of MDCK cells expressing scribble shRNA in a tetracycline-inducible manner (scribKD cells)

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