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The Probiotic L. casei Zhang Slows the Progression of Acute and Chronic Kidney Disease

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE176098 | GEO | 2021/07/15

REPOSITORIES: GEO

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The Probiotic L. casei Zhang Slows the Progression of Acute and Chronic Kidney Disease (scRNA-Seq)

Project description:The aim of this study is to explore the effects of L. casei Zhang on renal injury

2021-07-15 | GSE176097 | GEO

The Probiotic L. casei Zhang Slows the Progression of Acute and Chronic Kidney Disease (RNA-Seq)

Project description:The aim of this study is to explore the effects of L. casei Zhang on renal injury

2021-07-15 | GSE176096 | GEO

The Probiotic L. casei Zhang Slows the Progression of Acute and Chronic Kidney Disease

Project description:The Probiotic L. casei Zhang Slows the Progression of Acute and Chronic Kidney Disease

| PRJNA734940 | ENA

The Probiotic L. casei Zhang Slows the Progression of Acute and Chronic Kidney Disease (scRNA-Seq)

Project description:The Probiotic L. casei Zhang Slows the Progression of Acute and Chronic Kidney Disease (scRNA-Seq)

| PRJNA735041 | ENA

The Probiotic L. casei Zhang Slows the Progression of Acute and Chronic Kidney Disease (RNA-Seq)

Project description:The Probiotic L. casei Zhang Slows the Progression of Acute and Chronic Kidney Disease (RNA-Seq)

| PRJNA735046 | ENA

<i>Lactobacillus casei</i> Zhang exerts probiotic effects to antibiotic-treated rats.

Project description:Probiotics administration can facilitate the restoration of host gut microbiota/metabolome after antibiotic treatment. Yet, the mechanism behind such beneficial effects remains unclear. This study constructed a rat model of antibiotic-induced gut dysbiosis to monitor the effects and mechanism of probiotic (Lactobacillus casei Zhang) treatment in maintaining gut homeostasis and restoring the gut microbiota/metabolome. Forty rats were randomly divided into four groups (n = 10 per group): control receiving only saline (Ctrl), antibiotic (AB-Ctrl), antibiotic followed by probiotic (AB-Prob), and antibiotic plus probiotic followed by probiotic (AB + Prob). Rat fecal microbiota and sera were collected at four time points from pre-treatment to post-treatment. The probiotic-treated group (AB + Prob) had significantly more Parabacteroides (P.) goldsteinii after one week of antibiotic and probiotic intervention but fewer antibiotic resistance genes (ARGs)-possessing bacteria (Clostridioides difficile and Burkholderiales bacterium). Consistently, metabolomics data revealed that both probiotic groups had more acetic acid, propionic acid, butyric acid, and valeric acid post treatment. Moreover, a potential probiotic species, P. goldsteinii, strongly correlated with L. casei, as well as propionic acid, butyric acid, and valeric acid. Furthermore, administering probiotic lowered the serum IL-1α level. In contrast, the antibiotic-recipients had a higher irreversible level of IL-1α, suggesting inflammation of the rats. Thus, antibiotic treatment not only led to host gut dysbiosis, but inflammatory responses and an increase in gut ARGs. Daily L. casei Zhang supplementation could alleviate the side effect of cefdinir intervention and facilitate the restoration of gut microbial homeostasis, and these probiotic effects might involve P. goldsteinii-mediated beneficial activities.

| S-EPMC8573083 | biostudies-literature

Transcriptome analysis of probiotic Lactobacillus casei Zhang during fermentation in soymilk

Project description:Lactobacillus casei Zhang is a probiotic bacterium isolated from koumiss in Inner Mongolia of China. Gene expression dynamics of L. casei Zhang during growth in soymilk was investigated in attempt to reveal the mechanisms involved in growth stimulation for growing probiotics in. Comparison of different transcripts next to each other revealed 162 and 63 significantly induced genes in late logarithmic phase and stationary phase, of which the expression was at least 3 fold up-regulated and down-regulated, respectively. Approximately, 38.4% of the up-regulated genes were associated with amino acid transport and metabolism notably for histidine and lysine biosynthesis, followed by genes/gene clusters involved in carbohydrate transport and metabolism, lipid transport and metabolism, and inorganic ion transport and metabolism. The analysis results suggest that the stimulatory effect of soymilk-based ecosystem on the L. casei Zhang growth is more complex than amino acids or oligopeptides supply.

2011-12-31 | GSE23652 | GEO

Transcriptome analysis of probiotic Lactobacillus casei Zhang during fermentation in soymilk

2011-12-31 | E-GEOD-23652 | biostudies-arrayexpress

Effect of probiotic Lactobacillus casei Zhang on liver gene expression of hypercholesterolemic rats

Project description:The hypocholesterolemic effect of probiotics has been observed, but the molecular mechanism of probiotic-host interaction is still obscure. In this study, DNA microarray technology was used to explore the gene expression profile of liver of hypercholesterolemic rats caused by administration of probiotic Lactobacillus casei Zhang, which can decrease the serum triglyceride, low-density lipoprotein cholesterol, hepatic cholesterol and triglyceride of hypercholesterolemic rats.

2011-12-31 | GSE23740 | GEO

Folate-conjugated rapamycin slows progression of polycystic kidney disease.

Project description:Activation of the mammalian target of rapamycin (mTOR) signaling pathway is aberrant in autosomal-dominant polycystic kidney disease (ADPKD). The mTOR inhibitors, such as rapamycin, ameliorate PKD in rodent models, but clinical trials have not shown benefit, possibly as a result of low tissue concentrations of rapamycin at clinically tolerable doses. To overcome this limitation, we synthesized a folate-conjugated form of rapamycin (FC-rapa) that is taken up by folate receptor-mediated endocytosis and cleaved intracellularly to reconstitute the active drug. We found that renal cyst-lining cells highly express the folate receptor in ADPKD and mouse models. In vitro, FC-rapa inhibited mTOR activity in a dose- and folate receptor-dependent manner. Treatment of a PKD mouse model with FC-rapa inhibited mTOR in the target tissue, strongly attenuated proliferation and growth of renal cysts and preserved renal function. Furthermore, FC-rapa inhibited mTOR activity in the kidney but not in other organs. In summary, these results suggest that targeting the kidney using FC-rapa may overcome the significant side effects and lack of renal efficacy observed in clinical trials with mTOR inhibitors in ADPKD.

| S-EPMC3458469 | biostudies-literature

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